A quick way to crack an antonym question is to first build a simple sentence with the given word, then test each option in that same sentence to see which one flips the meaning completely. Take the sentence: Smoking has a pernicious effect on the lungs, meaning smoking damages the lungs slowly and seriously.
Testing the sentence swap shows that only healthy turns the meaning fully around, from destructive to beneficial. Innocuous merely cancels the harm without adding a positive quality, so it is the second best choice, not the best one.
Let's summarize:
So the correct opposite of pernicious is option (2), Healthy.