Question:medium

With the addition of linking number (Lk) by +2 to a relaxed DNA consisting of Lk = 200, which of the following occurs?

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Understand the relationship between linking number, supercoiling, and DNA topology.
Updated On: Feb 11, 2026
  • DNA undergo positive supercoiling with the Lk 202
  • DNA undergo positive supercoiling with the Lk 198
  • DNA undergo negative supercoiling with the Lk 202
  • Structure does not change
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The Correct Option is A

Solution and Explanation

The linking number (Lk) quantifies a DNA molecule's total twists and writhes. Increasing the linking number of relaxed DNA by +2 alters its topology, inducing positive supercoiling. The resulting linking number, Lk = 202, generates torsional stress and a more tightly coiled DNA structure.

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