Question

Match List I with List II:

List I	List II
(A) Histone erasers	(III) Deacetylases
(B) Histone readers	(IV) Bromodomain proteins
(C) Histone writers	(I) Methyltransferase
(D) DNA unwinding	(II) Topoisomerase

Choose the correct answer from the options given below:

• (A) - (II), (B) - (IV), (C) - (I), (D) - (III)
• (A) - (I), (B) - (III), (C) - (II), (D) - (IV)
• (A) - (I), (B) - (II), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

Understand the roles of histone modifiers and related proteins in gene expression and chromatin remodeling.

Answer 1

The Correct Option is A

- Histone erasers, exemplified by Topoisomerase, remove methyl groups from histones, thus altering gene expression.
- Histone readers' activity is facilitated by bromodomain proteins, which bind to acetylated lysines.
- Histone writers identify histone modifications (e.g., acetylation or methylation), subsequently mediating chromatin remodeling.
- Regarding DNA unwinding, enzymes such as deacetylases either add or remove acetyl groups, thereby regulating DNA accessibility.