DNA gyrase, a type II topoisomerase, negatively supercoils circular DNA. This reduces torsional strain, increasing DNA accessibility for enzymes and proteins, thereby aiding replication and transcription.
| List I | List II |
|---|---|
| (A) Histone erasers | (III) Deacetylases |
| (B) Histone readers | (IV) Bromodomain proteins |
| (C) Histone writers | (I) Methyltransferase |
| (D) DNA unwinding | (II) Topoisomerase |