Step 1: Understanding the Concept:
In Rheumatoid Arthritis (RA), DMARDs are drugs that slow down the progression of joint destruction. Non-DMARDs only treat the immediate symptoms like pain and swelling.
Step 2: Detailed Explanation:
1. Ibuprofen: It is an NSAID. It reduces pain and inflammation by inhibiting COX enzymes but has no effect on the underlying disease progression or joint damage.
2. DMARDs: Methotrexate (Gold standard) and Cyclophosphamide are conventional synthetic DMARDs. Infliximab is a biologic DMARD (anti-TNF). These drugs actively slow down the immune-mediated destruction of joints.
Step 3: Final Answer:
Among the options, Ibuprofen is classified as a purely symptomatic agent and is not a DMARD.