Question

A patient is started on isoniazid as part of antitubercular therapy. Vitamin _______

• A. K
• B. C
• C. A
• D. B\(_6\)

Hint:

Isoniazid can cause peripheral neuropathy, so pyridoxine or vitamin B\(_6\) is given prophylactically.

Answer 1

The Correct Option is D

Step 1: Understanding the Concept:
Isoniazid (INH) is a cornerstone drug for tuberculosis, but it interferes with the metabolism of certain vitamins.
Step 2: Detailed Explanation:
1. Side Effect: INH can cause peripheral neuropathy (tingling, numbness, pain in limbs).
2. Mechanism: INH reacts with and depletes the body's supply of Vitamin B6 (Pyridoxine). It also inhibits the enzyme pyridoxine phosphokinase, which is needed to activate B6.
3. Prevention: To prevent this nerve damage, a small dose (10–50 mg) of Pyridoxine is routinely prescribed alongside Isoniazid.
Step 3: Final Answer:
Pyridoxine (B6) supplementation is mandatory for patients on Isoniazid therapy to prevent drug-induced neuropathy.