Question

______ class of antihypertensive drugs is contraindicated due to teratogenic effects on the fetus in pregnant women with hypertension.

• A. Thiazide diuretics
• B. Beta blockers
• C. ACE inhibitors
• D. Calcium channel blockers

Hint:

ACE inhibitors are contraindicated in pregnancy because they can cause serious fetal toxicity.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
Teratogenicity refers to the ability of a drug to cause birth defects or fetal harm. Several antihypertensives are unsafe during pregnancy.
Step 2: Detailed Explanation:
1. ACE Inhibitors: Angiotensin-Converting Enzyme (ACE) inhibitors (like Enalapril, Lisinopril) and ARBs are strictly contraindicated in the second and third trimesters.
2. Fetal Harm: They interfere with fetal kidney development, leading to oligohydramnios (low amniotic fluid), fetal renal failure, and skull abnormalities.
3. Safe Alternatives: For pregnancy-induced hypertension, drugs like Methyldopa or Labetalol are typically preferred.
Step 3: Final Answer:
ACE inhibitors are known teratogens that can cause severe renal and developmental issues in the fetus.