The 'One gene-one enzyme' hypothesis was challenged by several researchers for its validity. The reasons are-
(A). Many enzymes are composed of more than one polypeptide encoded by different genes.
(B). Product of many genes are not enzymes
(C). Genes contain introns, which do not codes for any amino acids
(D). Several related polypeptides can be obtained from a single gene through alternate splicing
Choose the correct answer from the options given below:
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To challenge "one gene-one enzyme", look for factors that break the 1-to-1 ratio, such as: multi-subunit enzymes (A), non-enzyme products (B), and alternative splicing (D).