Histone H1, known as the linker histone, binds to the DNA entering and exiting the nucleosome core, stabilizing the chromatin's higher-order structure. Unlike core histones (H2A, H2B, H3, H4), H1 is not part of the nucleosome octamer; instead, it associates with linker DNA between nucleosomes, promoting chromatin compaction.
| List I | List II |
|---|---|
| (A) Histone erasers | (III) Deacetylases |
| (B) Histone readers | (IV) Bromodomain proteins |
| (C) Histone writers | (I) Methyltransferase |
| (D) DNA unwinding | (II) Topoisomerase |