Question

__________drug is mostly considered as first-line therapy for uncomplicated urinary tract infection (UTI) in a young, non-pregnant woman.

• A. Gentamicin injection
• B. Nitrofurantoin
• C. Amoxicillin
• D. Ciprofloxacin

Hint:

Nitrofurantoin is commonly preferred for uncomplicated lower UTI because it achieves high urinary concentration.

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
Uncomplicated UTI (cystitis) is usually caused by \textit{E. coli}. First-line treatment should be an antibiotic that reaches high concentrations in the urine and has low collateral damage to the body's normal flora.
Step 2: Detailed Explanation:
1. Nitrofurantoin: It is highly concentrated in the bladder and is very effective against common UTI pathogens. It has a low risk of systemic side effects and minimal resistance compared to other drugs.
2. Ciprofloxacin: While effective, it is now considered a second-line option for uncomplicated UTIs due to concerns about increasing resistance and potential long-term side effects (tendonitis).
3. Amoxicillin: Most \textit{E. coli} strains are now resistant to amoxicillin, making it a poor first-line choice.
4. Gentamicin: This is an injectable aminoglycoside reserved for severe or hospital-acquired complicated UTIs.
Step 3: Final Answer:
Current clinical guidelines recommend Nitrofurantoin as a primary first-line oral agent for uncomplicated cystitis.