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Disorder caused due to accumulation of amyloid proteins in CNS.

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When considering diseases linked to amyloid protein accumulation, Alzheimer's disease (AD) is the most well-known, but cerebral amyloid angiopathy (CAA) is another important condition to consider. Both involve amyloid buildup but affect different parts of the CNS.
Updated On: Nov 26, 2025
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Abnormal accumulation of amyloid proteins in the central nervous system (CNS) results in various neurological disorders. Alzheimer's disease (AD), a prevalent disorder, is characterized by amyloid plaque buildup in the brain, primarily beta-amyloid proteins. These plaques impede neuronal communication and cause neurodegeneration, a hallmark of AD. Similarly, cerebral amyloid angiopathy (CAA) involves amyloid deposits impacting brain blood vessels, elevating stroke and hemorrhage risk. Consequently, both Alzheimer's disease and cerebral amyloid angiopathy stem from amyloid protein accumulation within the CNS.
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