Question:medium
Which one of the following is a function of PGI2 (prostacyclin)?
Which one of the following is a function of PGI2 (prostacyclin)?
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Prostacyclin opposes thromboxane and relaxes smooth muscle - more than one statement fits.
Updated On: Jun 23, 2026
- Inhibits platelet aggregation
- Is a vasodilator
- Is pyrogenic like PGE2
- All of the above
Show Solution
The Correct Option is D
Solution and Explanation
Step 1: Prostacyclin ($PGI_2$) is the dominant prostanoid released by healthy endothelium and is the physiological counterweight to platelet-derived thromboxane $A_2$.
Step 2: By elevating intraplatelet $cAMP$, it strongly blocks platelet clumping, so the antiaggregatory claim holds.
Step 3: Acting through smooth muscle relaxation, it widens both blood vessels and bronchi, confirming its vasodilator and bronchodilator nature.
Step 4: Sharing the febrile property of $PGE_2$, it can reset the hypothalamic set point and is therefore pyrogenic.
Step 5: Since every listed property is genuine, the only internally consistent choice is the combined one.
\[\boxed{\text{All of the above}}\]
Step 2: By elevating intraplatelet $cAMP$, it strongly blocks platelet clumping, so the antiaggregatory claim holds.
Step 3: Acting through smooth muscle relaxation, it widens both blood vessels and bronchi, confirming its vasodilator and bronchodilator nature.
Step 4: Sharing the febrile property of $PGE_2$, it can reset the hypothalamic set point and is therefore pyrogenic.
Step 5: Since every listed property is genuine, the only internally consistent choice is the combined one.
\[\boxed{\text{All of the above}}\]
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