Step 1: Recall what enzymes are.
Enzymes are biological catalysts that speed up reactions without being used up.
Step 2: Understand activation energy.
Every reaction needs a minimum push called activation energy to start; a lower barrier means a faster reaction.
Step 3: Role of the enzyme.
An enzyme binds the substrate at its active site and lowers the activation energy, so the reaction runs quickly.
Step 4: Reject option 1.
Enzymes are not permanently consumed; they are reused again and again, so option 1 is wrong.
Step 5: Reject options 3 and 4.
Enzymes lower, not raise, activation energy, so option 3 is wrong, and enzymes are mostly proteins (organic), so option 4 is wrong.
Step 6: Conclude.
The correct statement is that enzymes lower activation energy, which is option 2.
\[ \boxed{\text{Enzymes lower activation energy of reaction}} \]