Which of the following enzymes is directly inhibited by statins to reduce cholesterol biosynthesis in the liver?

Question

Name the class of enzyme that usually catalyzes the following reaction: \[ S - G + S^{\prime} \rightarrow S + S^{\prime} - G \] Where \( G \) represents a group other than hydrogen, \( S \) is a substrate, and \( S^{\prime} \) is another substrate.

Answer 1

Statins lower cholesterol by inhibiting HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase). This enzyme is crucial for an early, rate-limiting step in liver cholesterol biosynthesis. Statins block this enzyme, reducing intracellular cholesterol synthesis. This leads to an increase in LDL receptors, thus enhancing LDL removal from the blood. Option (a) Lipase degrades lipids but does not participate in cholesterol synthesis. Option (c) Amylase aids in carbohydrate digestion. Option (d) Pepsin digests proteins in the stomach. Only option (b) is relevant to cholesterol synthesis, thus identifying it as the correct choice.

Which of the following enzymes is directly inhibited by statins to reduce cholesterol biosynthesis in the liver?

Show Hint

The Correct Option is B

Solution and Explanation

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