- Heat from acid-base neutralization is proportional to the product of acid and base molarities and volumes.- The combination yielding the maximum heat release will have the highest product of molarities and volumes.- Comparing the options, the mixture of 50 mL HCl and 20 mL NaOH will produce the greatest heat increase, as it involves a strong acid and strong base, maximizing heat generation. Final Answer: Option (3).