The goal is to select 2 vowels and 2 consonants from the unique letters of 'INCONSEQUENTIAL' and arrange them into 4-letter words.
Vowels present: I, O, E, U, A. (Count: 5 unique vowels)
Consonants present: N, C, S, Q, T, L. (Count: 6 unique consonants)
Number of ways to select 2 vowels from 5: $^5C_2 = 10$.
Number of ways to select 2 consonants from 6: $^6C_2 = 15$.
Once we have chosen our 4 letters, they are all distinct (since the problem states 'without repeating any letter'). The number of ways to arrange 4 distinct items in a row is given by $P(4,4) = 4!$.
Total arrangements = (Selection of Vowels) $\times$ (Selection of Consonants) $\times$ (Arrangement of 4 letters)
Total arrangements = $^5C_2 \times ^6C_2 \times 4!$
Total arrangements = $10 \times 15 \times 24 = 3600$.