Question

The maximum dose of PGF2 alpha (15-methyl prostaglandin F2 alpha, carboprost) in postpartum haemorrhage (PPH) is:

• A. 2000 micrograms
• B. 200 micrograms
• C. 2 mg
• D. 20 mg

Hint:

0.25 mg per dose, up to 8 doses gives the cumulative maximum.

Answer 1

The Correct Option is C

Step 1: Start from the unit dose. Carboprost is administered as 250 microgram aliquots by the intramuscular route for refractory uterine atony.
Step 2: Dosing can be repeated at 15 minute intervals, but the protocol caps the number of injections at eight to limit prostaglandin side effects.
Step 3: Multiply the unit dose by the cap: $250\ \mu g \times 8 = 2000\ \mu g = 2\ mg$. This is the ceiling total dose.
Step 4: So the maximum dose is 2 mg, and asthma is the key contraindication to remember alongside it.
\[\boxed{2\ mg}\]