Topic: Surgical management of Postpartum Hemorrhage (PPH) -- Devascularization.
When conservative medical measures fail (oxytocin, ergometrine, misoprostol, tranexamic acid), surgical devascularization is performed in a stepwise manner to preserve the uterus:
Step 1 -- Uterine artery ligation (O'Leary stitch):
Bilateral ligation of uterine arteries just below the level of lower uterine segment. Cuts off the dominant blood supply.
Step 2 -- Ovarian artery ligation:
Ligates the utero-ovarian arcade (collateral supply from ovarian vessels via the anastomosis with uterine artery).
Step 3 -- Internal iliac (hypogastric) artery ligation:
Ligation of the anterior division reduces pelvic arterial pulse pressure by $\sim$85%. Pioneered by Howard Kelly for cervical cancer bleeding, later applied to PPH.
The sequence follows the anatomical hierarchy of uterine blood supply:
\[\text{Uterine a.} \rightarrow \text{Ovarian a.} \rightarrow \text{Internal iliac a.}\]
If all fail: Hysterectomy (definitive).
\[\boxed{\text{Uterine artery, Ovarian artery, Internal iliac artery}}\]