Work by the field is $W = \vec{E}\cdot\vec{d}$, so only the part of the displacement that lies along $\vec{E}$ contributes.
A direction vector for the line $2x + 3y = 5$ can be found from its slope. Rearranged, $y = -\tfrac{2}{3}x + \tfrac{5}{3}$, so a step along the line looks like $\vec{d} = (3,\,-2)$ (moving $+3$ in $x$ drops $-2$ in $y$).
Now dot it with the field:\[\vec{E}\cdot\vec{d} = (2)(3) + (3)(-2) = 6 - 6 = 0.\]The field is at right angles to the line, so no matter how far the particle travels along $3y + 2x = 5$, the field does no work on it.\[\boxed{W = 0}\]