Step 1: Understand what is being asked.
We are given three vertices $A(-4,1)$, $B(4,5)$, $C(6,1)$ of a parallelogram $ABCD$ and need the fourth vertex $D$. Instead of using the midpoint of diagonals, let us use the fact that opposite sides of a parallelogram are equal and parallel.
Step 2: Use the parallel-side property.
In parallelogram $ABCD$, side $AB$ is parallel to and equal in length to side $DC$, and both point in the same direction when we go from $A$ to $B$ and from $D$ to $C$. This means:
\[ \overrightarrow{AB} = \overrightarrow{DC} \]
Step 3: Write this condition in coordinates.
$\overrightarrow{AB}$ is the change in coordinates going from $A$ to $B$:
\[ \overrightarrow{AB} = (4-(-4),\ 5-1) = (8,4) \]
Let $D=(x,y)$. Then $\overrightarrow{DC}$ is the change in coordinates going from $D$ to $C$:
\[ \overrightarrow{DC} = (6-x,\ 1-y) \]
Step 4: Equate and solve for $D$.
Since $\overrightarrow{AB}=\overrightarrow{DC}$:
\[ 6-x = 8 \implies x = 6-8 = -2 \]
\[ 1-y = 4 \implies y = 1-4 = -3 \]
Final Answer:
The fourth vertex $D$ is $(-2,-3)$, matching option (A).
\[ \boxed{D(-2,-3)} \]