Question

Spindle fibers attach to kinetochores of chromosomes during

• A. Prophase
• B. Metaphase
• C. Anaphase
• D. Telophase

Answer 1

The Correct Option is B

Spindle fiber attachment to kinetochores of chromosomes during cell division occurs during specific stages of mitosis: Prophase, Metaphase, Anaphase, and Telophase.

1. Prophase: Chromosomes condense and become visible. The nuclear envelope disintegrates, and spindle fibers assemble but do not yet connect to kinetochores.
2. Metaphase: This is the critical phase for spindle fiber attachment to chromosomal kinetochores. These attachments facilitate the alignment of chromosomes at the cell's equator, termed the metaphase plate.
3. Anaphase: Spindle fibers contract, drawing sister chromatids towards opposing cellular poles.
4. Telophase: Chromosomes arrive at the poles, nuclear envelopes reform, and chromosome decondensation commences.

Therefore, spindle fibers attach to kinetochores in Metaphase.