Question

All of the following drugs may cause hirsutism, except:

• A. Danazol
• B. Phenytoin
• C. Norethisterone
• D. Flutamide

Hint:

One drug is an antiandrogen used to treat the very condition.

Answer 1

The Correct Option is D

Hirsutism is fundamentally an androgen-driven problem, so the trick is to find the agent that lowers androgen action rather than raising it.

Three options push androgens up or mimic them. Danazol is itself a synthetic androgen, so unwanted hair is a predictable side effect. Norethisterone is a 19-nortestosterone progestin that retains androgenic character, again favouring hirsutism and acne. Phenytoin works through a different route but is a classic drug cause of excess hair growth and coarse skin.

Flutamide is the mirror image. It is a pure androgen-receptor antagonist, and clinicians prescribe it to suppress androgen-dependent hair growth. A drug used to treat hirsutism cannot be the one that causes it.

So the exception is the antiandrogen.
\[\boxed{\text{Flutamide}}\]