Question

Predominantly sensory neuropathy is/are caused by:

• A. Cisplatin
• B. Pyridoxine excess
• C. Suramin
• D. a and b

Hint:

Both a platinum chemotherapy agent and an excess of vitamin B6 hit the dorsal root ganglion.

Answer 1

The Correct Option is D

Step 1: Frame this around drugs that target the dorsal root ganglion (DRG). When the DRG is poisoned, the sensory cell bodies degenerate, giving a clinically pure or predominantly sensory picture with numbness, tingling, and loss of position sense.

Step 2: Cisplatin is a prototype DRG toxin. Patients on platinum therapy develop reduced vibration sense and sensory ataxia, confirming a sensory-predominant neuropathy, so the cisplatin option qualifies.

Step 3: Megadoses of vitamin B6 (pyridoxine) are equally notorious for DRG injury, producing a sensory ataxic neuropathy. That makes the pyridoxine option also correct.

Step 4: Suramin instead behaves like a sensorimotor or demyelinating insult, so it is excluded. With two valid sensory agents on the list, the combined choice is required.

\[\boxed{\text{a and b - Cisplatin and Pyridoxine excess}}\]