Question

Which of the following is NOT a hepatotoxic drug?

• A. Chlorpropamide
• B. Allopurinol
• C. Streptomycin
• D. Halothane

Hint:

One of these is an oto and nephrotoxic aminoglycoside, not a liver toxin.

Answer 1

The Correct Option is C

Step 1: Identify the outlier whose toxicity does not involve the liver. Three options have a known hepatotoxic reputation.

Step 2: Halothane is famous for immune mediated halothane hepatitis. Chlorpropamide, an older sulfonylurea, can trigger cholestatic liver injury, and allopurinol can cause a severe hypersensitivity reaction that includes hepatitis.

Step 3: Streptomycin sits in a different toxicity bracket. As an aminoglycoside, its hallmark adverse effects are damage to the inner ear and to the kidneys.

Step 4: Since the liver is not the target organ for streptomycin toxicity, it is the drug that is not hepatotoxic.

\[\boxed{\text{Streptomycin}}\]