Step 1: Trisomy 21 Explained. Trisomy 21, the presence of an extra copy of chromosome 21, results in Down syndrome, a genetic condition.
Step 2: Down Syndrome Manifestations. Characteristic signs include: - A furrowed tongue (i) - A distinct palm crease (ii). Developmental delays and other attributes may also be present.
Name the mechanism of evolution that must have operated so that population-two evolved from population-one.

| List I | List II | ||
| A | Down’s syndrome | I | 11th chormosome |
| B | α-Thalassemia | II | ‘X’ chromosome |
| C | β-Thalassemia | III | 21st chromosome |
| D | Klinefelter’s syndrome | IV | 16th chromosome |