Step 1: Identify the lesion - the radiograph depicts a Giant cell tumor (osteoclastoma), a benign bone neoplasm typically found at the ends of long bones.
Step 2: Recall its classic features: an eccentric, expansile lytic lesion located in the metaphysis that grows into the epiphysis and abuts the articular surface, with a narrow zone of transition and a well-defined, non-sclerotic border.
Step 3: Evaluate each statement. The epiphyseal-to-metaphyseal location, the distinct margin, and the eccentric position are all genuine, well-documented features, so they are correct statements.
Step 4: Management of GCT is operative - extended curettage with bone grafting or PMMA cementation, sometimes wide resection for aggressive lesions. Chemotherapy has no primary role here, so calling it the treatment of choice is the false statement.
$\therefore$ the incorrect option is chemotherapy.
\[\boxed{\text{Chemotherapy is the treatment of choice}}\]