Question:medium
Which of the following statements is incorrect with respect to prasugrel?
Which of the following statements is incorrect with respect to prasugrel?
Show Hint
Prasugrel, like clopidogrel, must be activated - so it IS a prodrug.
Updated On: Jun 24, 2026
- Not a prodrug
- P2Y purinergic receptor blocker
- Has a strong antiplatelet activity
- Causes intracranial haemorrhage in TIA patients
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: This is a negative-stem item, so the correct choice is the false statement about prasugrel.
Step 2: Verify each true fact. Prasugrel belongs to the thienopyridine family, undergoes liver conversion to its active metabolite (so it is a prodrug), and then irreversibly shuts off the platelet $P2Y_{12}$ ADP receptor.
Step 3: Its activation is fast and near-complete, which is why its antiplatelet effect is potent and reliable, and why it carries a high bleeding risk that contraindicates it in prior stroke or TIA.
Step 4: The only statement that contradicts this profile is the claim that it is not a prodrug.
\[\boxed{\text{Not a prodrug (this statement is incorrect)}}\]
Step 2: Verify each true fact. Prasugrel belongs to the thienopyridine family, undergoes liver conversion to its active metabolite (so it is a prodrug), and then irreversibly shuts off the platelet $P2Y_{12}$ ADP receptor.
Step 3: Its activation is fast and near-complete, which is why its antiplatelet effect is potent and reliable, and why it carries a high bleeding risk that contraindicates it in prior stroke or TIA.
Step 4: The only statement that contradicts this profile is the claim that it is not a prodrug.
\[\boxed{\text{Not a prodrug (this statement is incorrect)}}\]
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