Question

Which of the following reagents are used to prepare primary amines by Hofmann bromamide degradation reaction?

• A. (i), (ii) and (iv)
• B. (i) and (iii)
• C. (i), (ii) and (iii)
• D. (i), (iii) and (iv)

Hint:

{Hofmann Rearrangement Shortcut:} Amide \( \rightarrow \) Amine with {one carbon less}. Reagents to remember: \[ Br_2 + NaOH \quad (\text{basic bromine}) \]

Answer 1

The Correct Option is C

The question asks which reagents are used for the preparation of primary amines via Hofmann bromamide degradation reaction. Let's understand the Hofmann bromamide degradation reaction:

Hofmann Bromamide Reaction: This reaction involves the conversion of an amide to a primary amine with one carbon atom less. The reagents used in this process are bromine (Br₂) and a strong base, typically sodium hydroxide (NaOH).

1. The starting material is an amide, indicated as \(RCONH_2\).
2. The reagents involved are:
   • (i) Amide (\(RCONH_2\))
   • (ii) NaOH
   • (iii) Br₂
   • (iv) CHCl₃ (not used in this reaction)
3. The presence of NaOH and Br₂ facilitates the transformation of the amide into an amine.

Based on the details provided, the correct reagents for the Hofmann bromamide degradation reaction are:

• (i) Amide
• (ii) NaOH
• (iii) Br₂

Hence, the correct answer is: (i), (ii) and (iii).