Question

Assertion (A): Aliphatic primary amines can be prepared by Gabriel phthalimide synthesis. Reason (R): Alkyl halides undergo nucleophilic substitution with anion formed by phthalimide.

• A. Both Assertion (A) and Reason (R) are true and Reason (R) is the correct explanation of the Assertion (A).
• B. Both Assertion (A) and Reason (R) are true, but Reason (R) is not the correct explanation of the Assertion (A).
• C. Assertion (A) is true, but Reason (R) is false
• D. Assertion (A) is false, but Reason (R) is true.

Hint:

Gabriel synthesis is not suitable for aryl amines, as aryl halides do not undergo SN2 substitution.

Answer 1

The Correct Option is A

- Primary aliphatic amines are synthesized using the Gabriel phthalimide synthesis, which involves the reaction of phthalimide with alkyl halides. An intermediate is formed and subsequently hydrolyzed to produce the amine. - The process proceeds through a nucleophilic substitution (SN2 mechanism), where the phthalimide anion acts as the nucleophile, attacking the alkyl halide. - Given that both the assertion and the reason are accurate, and the reason adequately explains the assertion, option (A) is the correct choice.