Question

Which of the following is used as a clot buster ?

• A. Statins
• B. Streptokinase
• C. Penicillin
• D. Cyclosporin A

Hint:

• Mnemonic for Sources: itemize

• Streptococcus \(\rightarrow\) Streptokinase (Clot buster)

• Monascus purpureus \(\rightarrow\) Statins (Cholesterol reducer)

• Trichoderma polysporum \(\rightarrow\) Cyclosporin A (Immunosuppressant)
Genetic engineering is used to modify natural streptokinase to minimize potential allergic reactions and improve its targeted efficacy in patients. itemize

Answer 1

The Correct Option is B

Step 1: Understand the term clot buster.
A clot buster, or thrombolytic agent, dissolves blood clots inside vessels and is used in heart attack and stroke to restore blood flow.
Step 2: Check statins.
Statins are made by the yeast Monascus purpureus and lower blood cholesterol by inhibiting HMG-CoA reductase. They do not dissolve clots, so wrong.
Step 3: Check streptokinase.
Streptokinase is produced from the bacterium Streptococcus. It activates plasminogen into plasmin, which breaks down the fibrin in clots. This is a true clot buster.
Step 4: Check penicillin.
Penicillin from Penicillium notatum is an antibiotic that targets bacterial cell walls, not clots, so wrong.
Step 5: Check cyclosporin A.
Cyclosporin A from the fungus Trichoderma polysporum is an immunosuppressant used in organ transplants, not for clots, so wrong.
Step 6: Conclude.
Streptokinase is the microbial product used as a clot buster.
\[ \boxed{\text{Streptokinase}} \]