Question

Which of the following is an indicator of active multiplication of the hepatitis B virus?

• A. HBsAg
• B. HBcAg
• C. HBeAg
• D. Anti-HBs

Hint:

Think about which hepatitis B marker is a secreted protein tied directly to viral replication, not just infection status.

Answer 1

The Correct Option is C

This question tests recognition of which hepatitis B serologic marker reflects active viral replication.

1. HBsAg: shows infection is present but stays positive in both actively replicating and quiescent carrier states, so it cannot be used to judge replication.
2. HBcAg: never appears free in serum because it is confined to the infected hepatocyte, so it is not a usable blood marker at all.
3. HBeAg: is a secreted, soluble protein only produced when the virus is actively replicating and packaging new virions, making it the direct marker of infectivity and viral turnover.
4. Anti-HBs: is the neutralizing antibody that appears after the virus has been cleared or after vaccination, marking immunity rather than active infection.

Correct answer: HBeAg