Step 1: Recall the CDC bioterrorism tiers, where Category A is reserved for the most dangerous, readily weaponised, high-mortality organisms.
Step 2: Among the choices, only anthrax meets the Category A criteria; it is highly transmissible as spores, has high lethality in the inhalational form, and demands special preparedness.
Step 3: Q fever (Coxiella), epidemic typhus (Rickettsia) and brucellosis are grouped under Category B, a tier of moderately transmissible agents with lower fatality rates, so they are excluded.
Step 4: The Category A agent in this list is anthrax.
\[\boxed{\text{Anthrax}}\]