Question:medium

Which of the following drugs is used for the long term management of obesity?

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Consider which drug class acts on GLP-1 receptors to reduce appetite and is approved for weight management.
Updated On: Jun 23, 2026
  • Sibutramine
  • Fenfluramine
  • Metformin
  • Liraglutide
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The Correct Option is D

Solution and Explanation

Classifying anti-obesity drugs:
$\text{Sibutramine}$ -- SNRI; withdrawn (cardiovascular toxicity).
$\text{Fenfluramine}$ -- Serotonin releaser; banned (valvulopathy).
$\text{Metformin}$ -- Biguanide; not approved for obesity per se.
$\text{Liraglutide (3 mg)}$ -- GLP-1 receptor agonist; acts on hypothalamic neurons to reduce appetite and prolongs satiety by delaying gastric emptying. It is the only option listed with regulatory approval for chronic weight management.

Key point: Bupropion + naltrexone (Contrave) is another approved combination, but liraglutide is the answer here.
\[\boxed{\text{Liraglutide}}\]
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