Osmotic pressure exhibits a direct proportionality to the particle count, as quantified by the van't Hoff factor ($i$). Specifically, CaCl$_2$ dissociates into three ions (one Ca$^{2+}$ and two Cl$^-$), whereas KCl yields two ions. Glucose and urea, conversely, do not ionize. Consequently, CaCl$_2$ generates the greatest number of particles, resulting in the highest osmotic pressure.