Question

Which from following reactions occurs by removal of -CO- group from amide ?

• A. Gabriel phthalimide synthesis
• B. Ammonolysis of halides
• C. Mendius reduction
• D. Hofmann degradation

Hint:

In Hofmann bromamide degradation the amide loses its carbonyl carbon as carbonate.

Answer 1

The Correct Option is D

Step 1: Carbon count
Look at the carbon count of the amine. Hofmann gives $\text{RNH}_2$ from $\text{RCONH}_2$, which has lost one carbon.

Step 2: Lost group
The lost carbon is the C=O carbon, ending up in $\text{Na}_2\text{CO}_3$.

Step 3: Others
Gabriel and ammonolysis keep the carbon count of the alkyl halide, and Mendius adds a carbon through the nitrile.

Step 4: Answer
Option (D).

Final Answer:
The answer is Hofmann degradation. This is option (D). \[ \boxed{\text{(D) }\text{Hofmann degradation}} \]