Question:medium
Which drug decreases the bone resorption in osteoporosis?
Which drug decreases the bone resorption in osteoporosis?
Show Hint
Look for the bisphosphonate that acts on osteoclasts, not the PTH analogue.
Updated On: Jun 23, 2026
- Teriparatide
- Risedronate
- Cortisone
- Cimetidine
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: Classify the options into bone-active categories. Drugs that reduce bone breakdown are anti-resorptive; drugs that stimulate formation are anabolic.
Step 2: Risedronate belongs to the nitrogen-containing bisphosphonate group. It is taken up by osteoclasts and disrupts their function, so they can no longer erode the bone surface, directly lowering resorption.
Step 3: Teriparatide, given as intermittent PTH, falls in the anabolic group; it improves skeletal microarchitecture by adding bone, not by suppressing osteoclasts, so it does not fit "decreases bone resorption."
Step 4: Cortisone promotes bone loss and is a cause of secondary osteoporosis, while cimetidine is unrelated to bone metabolism. The only true anti-resorptive listed is risedronate. \[\boxed{\text{Risedronate}}\]
Step 2: Risedronate belongs to the nitrogen-containing bisphosphonate group. It is taken up by osteoclasts and disrupts their function, so they can no longer erode the bone surface, directly lowering resorption.
Step 3: Teriparatide, given as intermittent PTH, falls in the anabolic group; it improves skeletal microarchitecture by adding bone, not by suppressing osteoclasts, so it does not fit "decreases bone resorption."
Step 4: Cortisone promotes bone loss and is a cause of secondary osteoporosis, while cimetidine is unrelated to bone metabolism. The only true anti-resorptive listed is risedronate. \[\boxed{\text{Risedronate}}\]
Was this answer helpful?
0
