Question

Which drug decreases the bone resorption in osteoporosis ?

• A. Teriparatide
• B. Risedronate
• C. Cortisone
• D. Cimetidine

Answer 1

The Correct Option is B

Step 1: Anti-resorptive therapy in osteoporosis means inhibiting osteoclast-driven bone breakdown, so we look for the bisphosphonate.

Step 2: Risedronate, an aminobisphosphonate, binds bone mineral and poisons osteoclasts, cutting down resorption and slowing remodelling. This makes it the correct anti-resorptive agent.

Step 3: Teriparatide is the opposite kind of drug, an anabolic PTH analog that stimulates new bone formation rather than reducing resorption.

Step 4: Cortisone worsens bone density and can induce osteoporosis, and cimetidine has no role in bone metabolism. Hence risedronate is the drug that decreases bone resorption.

\[\boxed{\text{Risedronate}}\]