Question

Which are the correct statements regarding INSDC....
(A). Promotion of Human Genome Project
(B). It is collaboration of GenBank, EMBL and DDBJ databases.
(C). Facilitating exchange of sequence data on daily basis
(D). Validation of 3D model of protein with respect to structure solved by either X-ray crystallography or NMR spectroscopy
Choose the correct answer from the options given below:

• (B) and (D) only.
• (A) and (B) only.
• (B) and (C) only.
• (C) and (D) only.

Hint:

Remember INSDC = \textbf{I}nternational \textbf{N}ucleotide \textbf{S}equence \textbf{D}atabase \textbf{C}ollaboration. The key is "Nucleotide Sequence." This helps you distinguish it from protein structure databases like PDB. The three main partners (NCBI/GenBank, ENA/EMBL, DDBJ) are essential to know.

Answer 1

The Correct Option is C

Step 1: Introduction
INSDC, the International Nucleotide Sequence Database Collaboration, is a partnership between major nucleotide sequence archives. The task is to identify accurate statements about this collaboration.
Step 2: Analysis of Statements
(A) Promotion of Human Genome Project: While vital for the Human Genome Project as a data repository, INSDC's scope is broader, encompassing all public sequence data from all organisms.
(B) Collaboration of GenBank, EMBL, and DDBJ: This accurately defines INSDC. It involves GenBank (NCBI, USA), the European Nucleotide Archive (ENA, EMBL-EBI, Europe), and the DNA Data Bank of Japan (DDBJ, Japan). This statement is correct.
(C) Daily Data Exchange: This is a core function of INSDC. The three databases synchronize data daily. Sequences submitted to any database are available in the others within 24 hours. This provides the scientific community with a complete, updated collection of public nucleotide sequences. This statement is correct.
(D) Validation of 3D protein models: This relates to structural bioinformatics and protein structure validation, primarily using the Protein Data Bank (PDB). INSDC focuses on nucleotide sequences (DNA, RNA), not protein structures. This statement is incorrect.
Step 3: Conclusion
The correct statements are (B) and (C): INSDC is a collaboration between GenBank, ENA (EMBL), and DDBJ, and they exchange data daily.