Question:medium
Which among the following is used for the diagnosis of antiphospholipid antibody syndrome?
Which among the following is used for the diagnosis of antiphospholipid antibody syndrome?
Show Hint
Recall the three APS lab criteria; do not confuse beta 2 glycoprotein I with beta 2 microglobulin.
Updated On: Jun 24, 2026
- Beta 2 microglobulin antibody
- Anti nuclear antibody
- Anti centromere antibody
- Anti beta 2 glycoprotein I antibody
Show Solution
The Correct Option is D
Solution and Explanation
Anchor the answer in the formal classification criteria for APS, which require a clinical event (clot or recurrent pregnancy loss) plus a laboratory antibody that stays positive on repeat testing 12 weeks later.
Only three antibody assays count toward the laboratory limb: lupus anticoagulant, anticardiolipin, and anti-beta 2 glycoprotein I. From the choices listed, the one that matches is the anti-beta 2 glycoprotein I antibody, an antibody directed against the plasma cofactor that mediates much of the prothrombotic effect in APS.
The trap option is beta 2 microglobulin antibody, which sounds similar but is a different molecule entirely (beta 2 microglobulin is a tumour and renal marker, not an antiphospholipid target). Antinuclear antibody is the lupus screen, and anti-centromere antibody flags limited scleroderma/CREST; neither is part of the APS criteria.
So the diagnostic test from this set is the anti-beta 2 glycoprotein I antibody.
\[\boxed{\text{Anti beta 2 glycoprotein I antibody}}\]
Only three antibody assays count toward the laboratory limb: lupus anticoagulant, anticardiolipin, and anti-beta 2 glycoprotein I. From the choices listed, the one that matches is the anti-beta 2 glycoprotein I antibody, an antibody directed against the plasma cofactor that mediates much of the prothrombotic effect in APS.
The trap option is beta 2 microglobulin antibody, which sounds similar but is a different molecule entirely (beta 2 microglobulin is a tumour and renal marker, not an antiphospholipid target). Antinuclear antibody is the lupus screen, and anti-centromere antibody flags limited scleroderma/CREST; neither is part of the APS criteria.
So the diagnostic test from this set is the anti-beta 2 glycoprotein I antibody.
\[\boxed{\text{Anti beta 2 glycoprotein I antibody}}\]
Was this answer helpful?
0
Top Questions on Antiphospholipid antibody syndrome diagnosis
- Which of the following is recommended in a woman with antiphospholipid antibodies and a history of prior abortions or still birth?
- NEET (PG) - 2010
- Medicine
- Antiphospholipid antibody syndrome diagnosis
- Antiphospholipid antibody (APLA) syndrome is associated with all of the following except:
- NEET (PG) - 2010
- Medicine
- Antiphospholipid antibody syndrome diagnosis
- Want to practice more? Try solving extra ecology questions todayView All Questions
