Question

Antiphospholipid antibody (APLA) syndrome is associated with all of the following except:

• A. Bleeding disorders
• B. Thrombotic disorders
• C. Coagulation disorders
• D. Recurrent fetal loss

Hint:

APLA syndrome causes clotting, not bleeding, despite the lupus anticoagulant name.

Answer 1

The Correct Option is A

The single idea to anchor here is that antiphospholipid syndrome makes blood clot too easily. Every true association flows from that pro-clotting tendency, and the false one breaks it.

Patients form clots in veins and arteries, giving deep vein thrombosis, pulmonary embolism, and stroke. That makes thrombotic disorders a real feature. The antibodies also interfere with phospholipid-dependent clotting assays, so laboratory coagulation results look abnormal, most famously a prolonged aPTT that fails to correct when mixed with normal plasma. That ties in coagulation disorders as a genuine link. In pregnancy the same clotting drive damages the placenta, producing repeated miscarriages, which is one of the formal diagnostic criteria, so recurrent fetal loss belongs as well.

What does not fit is bleeding. Despite the confusing label lupus anticoagulant, the term reflects only a test-tube prolongation, not actual hemorrhage in the body. Clinically these patients clot rather than bleed, so bleeding disorders is the odd statement out and the answer.
\[\boxed{\text{Bleeding disorders}}\]