Question:medium

What is the role of NAD(P)H as a component of Nitrate reductase in Nitrogen fixation?

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Remember the mnemonic OIL RIG: Oxidation Is Loss (of electrons), Reduction Is Gain (of electrons). In the reaction, NAD(P)H becomes NAD(P)⁺, losing electrons (Oxidation), so it must be the electron donor.
Updated On: Feb 18, 2026
  • As a prosthetic group
  • As a cofactor
  • As an electron donor
  • As an electron accepter
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The Correct Option is C

Solution and Explanation

Step 1: Concept Overview:
The question focuses on the function of NAD(P)H in the Nitrate reductase-catalyzed enzymatic reaction. Nitrate reductase is vital for nitrogen assimilation (not fixation) in plants, converting nitrate into a usable form.
Step 2: Detailed Explanation:
Nitrate reductase facilitates the reduction of nitrate (NO₃⁻) to nitrite (NO₂⁻). This initial step converts soil-absorbed nitrate into ammonia for amino acid synthesis. The redox reaction is: \[ \text{NO}_3^- + \text{NAD(P)H} + \text{H}^+ \xrightarrow{\text{Nitrate reductase}} \text{NO}_2^- + \text{NAD(P)}^+ + \text{H}_2\text{O} \] Reaction details:

Nitrate (NO₃⁻) is reduced by gaining electrons; thus, it is the electron acceptor.
NAD(P)H is oxidized by losing electrons (and a proton) to form NAD(P)⁺. Oxidized substances provide electrons.
Therefore, NAD(P)H acts as the electron donor, providing reducing power.
Step 3: Option Analysis:


(A) As a prosthetic group: Incorrect. Prosthetic groups are permanently bound, non-protein components. NAD(P)H is a transiently binding coenzyme (or cosubstrate).

(B) As a cofactor: While NAD(P)H is a cofactor (specifically a coenzyme), "electron donor" is a more precise descriptor of its chemical role in this reaction.

(C) As an electron donor: Correct. This accurately describes its function of donating electrons to reduce nitrate. This is the most specific and correct answer.

(D) As an electron accepter: Incorrect. Nitrate is the electron acceptor.

Step 4: Conclusion:
NAD(P)H's specific role in the nitrate reductase reaction is to donate electrons, enabling nitrate reduction.
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