Question

Which of the following enzyme is inhibited by citrate in Kreb's cycle?

• A. Phospho-fructo kinase II (PFKII)
• B. Aldolase
• C. Pyruvate kinase
• D. Phosphoglycerate mutase (PGM)

Hint:

Remember that citrate plays a role in feedback inhibition to regulate energy production efficiently.

Answer 1

The Correct Option is A

Citrate, a Kreb's cycle intermediate, inhibits Phospho-fructo kinase II (PFKII). PFKII is a critical glycolysis enzyme that regulates glucose metabolism. By inhibiting PFKII, citrate balances energy production between glycolysis and the Kreb's cycle, optimizing energy utilization.