Question

What is NOT true with regard to the adult polycystic kidney?

• A. Hematuria
• B. Hypertension is rare
• C. Autosomal dominant transmission
• D. Cysts are seen in the liver, spleen and pancreas

Hint:

Hypertension is one of the earliest and most common findings in ADPKD, not a rare one.

Answer 1

The Correct Option is B

Step 1: Understanding the Question:
We need the FALSE statement about adult (autosomal dominant) polycystic kidney disease.

Step 2: Key Formula or Approach:
Check each option against the standard features of ADPKD: urinary findings, blood pressure pattern, inheritance, and extrarenal organ involvement.

Step 3: Detailed Explanation:
Hematuria is a true feature, since cyst rupture or bleeding into a cyst commonly shows up as blood in the urine.
Autosomal dominant transmission is true and is the defining inheritance pattern of the disease, most often from a PKD1 gene mutation.
Cysts in the liver, spleen, and pancreas are true findings, since ADPKD is a systemic cystic disease and not limited to the kidneys.
Hypertension, however, is not rare in ADPKD. It is one of the most common findings and often develops before any drop in kidney function, driven by activation of the renin-angiotensin system within the enlarging kidneys. So the claim that hypertension is rare is false.

Step 4: Final Answer:
The false statement is that hypertension is rare in adult polycystic kidney disease.