Question

What is mechanism of action of colchicine in acute gout?

• A. Inhibition of purine metabolism
• B. Inhibition of uric acid conversion
• C. Migration of leukocytes
• D. Leukocytes, lymphocytes inhibition & microtubular inhibitor

Answer 1

The Correct Option is D

Step 1: Gout flares ignite when needle-like urate crystals drop into the joint fluid and white cells rush in. As they engulf the crystals they spill glycoprotein and lysosomal enzymes that amplify the inflammation.

Step 2: Colchicine, a plant alkaloid, works upstream by binding tubulin and preventing microtubules from forming. Without functioning microtubules, leukocytes and lymphocytes cannot crawl into the joint, and glycoprotein release is suppressed.

Step 3: Notice that colchicine never touches uric acid levels - it neither cuts its synthesis nor speeds its excretion - so the anti-purine options are wrong. The full and most accurate statement is inhibition of leukocyte and lymphocyte migration plus microtubule inhibition.

\[\boxed{\text{Leukocyte and lymphocyte migration inhibition and microtubular inhibition}}\]