Question:medium
Vasopressin acts through which channels in the collecting duct?
Vasopressin acts through which channels in the collecting duct?
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ADH inserts a specific aquaporin into the apical membrane of principal cells.
Updated On: Jun 23, 2026
- Aquaporin 1
- Aquaporin 2
- GLUT-1
- GLUT-4
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: The question asks which membrane channel ADH inserts to make the collecting duct water-permeable.
Step 2: ADH binds V2 receptors on principal cells, raising cyclic AMP, which triggers trafficking of stored water-channel vesicles to the apical surface.
Step 3: The specific channel shuttled into the apical membrane is aquaporin-2 (AQP2). Water then exits the cell basolaterally through aquaporins 3 and 4.
Step 4: Aquaporin 1 sits in the proximal nephron and is constitutive, while the GLUT family carries glucose, so none of these fit the ADH response. \[\boxed{\text{Aquaporin 2}}\]
Step 2: ADH binds V2 receptors on principal cells, raising cyclic AMP, which triggers trafficking of stored water-channel vesicles to the apical surface.
Step 3: The specific channel shuttled into the apical membrane is aquaporin-2 (AQP2). Water then exits the cell basolaterally through aquaporins 3 and 4.
Step 4: Aquaporin 1 sits in the proximal nephron and is constitutive, while the GLUT family carries glucose, so none of these fit the ADH response. \[\boxed{\text{Aquaporin 2}}\]
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