Question

A child presented with dehydration and was supplemented with ORS solution for management. Which of the following receptors help in the absorption of glucose from GIT?

• A. SGLT 1
• B. SGLT 2
• C. GLUT 1
• D. GLUT 2

Hint:

Think about which sodium-glucose co-transporter sits on the luminal brush border of intestinal cells.

Answer 1

The Correct Option is A

Key Concept: Glucose absorption from the intestinal lumen depends on SGLT (Sodium-Glucose Linked Transporter) proteins, not GLUT proteins.

SGLT 1 vs SGLT 2:
- $\text{SGLT 1}$: Located on the apical surface of small intestinal enterocytes; co-transports 2 $Na^+$ per 1 glucose molecule; the primary intestinal glucose and galactose transporter.
- $\text{SGLT 2}$: Located in proximal renal tubule; reabsorbs ~90% of filtered glucose from urine; target of gliflozin drugs.

ORS Mechanism:
ORS contains sodium and glucose in a specific ratio. Sodium enters the enterocyte via SGLT 1 along its electrochemical gradient, dragging glucose in simultaneously. Water follows osmotically, restoring hydration. GLUT 1 and GLUT 2 operate on the basolateral side or in other tissues -- they do not drive luminal uptake.

Answer: \[\boxed{\text{SGLT 1}}\]