Question

Transcription factors that mediate the binding of RNA polymerase to DNA template are
A. TFIIA
B. TATA box
C. TFIIB
D. Small nuclear ribonucleoproteins
Choose the correct answer from the options given below:

• A. A and D
• B. A and C
• C. C and D
• D. B and D

Hint:

Focus on the roles of transcription factors in stabilizing RNA polymerase binding during transcription initiation.

Answer 1

The Correct Option is B

Transcription factors are proteins that facilitate RNA polymerase binding to the DNA template, thereby initiating and regulating transcription. Reviewed options include:
- TFIIA: This general transcription factor stabilizes TFIID's (containing the TATA-binding protein) attachment to the promoter, vital for transcription initiation complex formation. - TATA box: A DNA sequence in the promoter, not a transcription factor itself, serving as a binding site for factors like TFIID. -
TFIIB: This transcription factor is instrumental in recruiting and stabilizing RNA polymerase II's binding to the promoter during initiation. - Small nuclear ribonucleoproteins (snRNPs): These are involved in RNA splicing, not directly in transcription initiation.
Therefore, TFIIA and TFIIB are the transcription factors that mediate RNA polymerase binding to the DNA template.