Question:medium

Which of the following enzyme is defective in galactosemia—a fatal genetic disorder in infants?

Show Hint

Focus on the enzymes involved in galactose metabolism and their roles in preventing toxic accumulation.
Updated On: Feb 11, 2026
  • Glucokinase
  • Galactokinase
  • UDP-galactose 4-epimerase
  • Galactose-1-phosphate uridyltransferase
Show Solution

The Correct Option is D

Solution and Explanation

Galactosemia stems from a deficiency in galactose-1-phosphate uridyltransferase (GALT). This enzyme is essential for converting galactose-1-phosphate to UDP-galactose, a critical step in galactose metabolism. Its absence leads to a toxic accumulation of galactose-1-phosphate, causing severe complications such as liver damage, developmental delays, and cataracts.

Was this answer helpful?
0

Top Questions on Molecular Genetics

Questions Asked in CUET (PG) exam