Step 1: Split the hand into the ace and the rest.
A valid hand needs exactly one of the 4 aces, plus the remaining 4 cards drawn from the 48 non-ace cards.
Step 2: Count each part separately.
Choosing the ace: \(\binom{4}{1}=4\)
Choosing the other four cards: \(\binom{48}{4}=\frac{48\times47\times46\times45}{4\times3\times2\times1}=194580\)
Step 3: Multiply the independent choices.
\[ 4\times194580=778320 \]