Question

The most common karyotype in true hermaphroditism is:

• A. 45 X0 with streak gonads
• B. 46 XX with ovotestis
• C. 47 XY +9
• D. 47 XX

Hint:

About 90 percent of true hermaphrodites are 46 XX with an ovotestis.

Answer 1

The Correct Option is B

Step 1: Define the entity first. True hermaphroditism (ovotesticular DSD) requires histological proof of both ovarian and testicular tissue, classically as an ovotestis, and the question asks for its commonest chromosomal pattern.
Step 2: Epidemiologically, roughly nine out of ten such patients carry a 46 XX karyotype while still developing testicular tissue. So the answer pairing the commonest karyotype with the defining gonad is 46 XX with ovotestis, which is option B.
Step 3: Exclude the distractors. 45 X0 with streak gonads describes Turner syndrome; 47 XY +9 is an irrelevant trisomy; 47 XX is not a valid configuration for this disorder. Mosaic 46 XX / 46 XY can rarely cause it, but the single most frequent finding remains 46 XX.
\[\boxed{\text{46 XX with ovotestis}}\]